CodeRunner

Bi-sdAb (bispecific single domain antibody) is a novel antibody format engineered for enhanced therapeutic efficacy. It is structurally composed of two distinct single-domain antibodies (sdAbs), each recognizing a different antigen or epitope, linked together by a flexible linker. This unique configuration allows for high-affinity binding to two targets simultaneously. Construction typically involves genetic fusion of the sdAb variable regions, often derived from camelid heavy-chain antibodies, into a single polypeptide chain. Key characteristics include enhanced tissue penetration, reduced immunogenicity, and facile manufacturability. Bi-sdAbs are designed for precise dual-targeting, enabling novel mechanisms of action such as redirecting immune effector cells, blocking two distinct pathways simultaneously, or bridging two cell types for therapeutic benefit.