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Bispecific-rd
Protein aggregation is a primary concern in the development of recombinant antibody therapeutics in the biotechnology industry. Aggregates may have unpredictable consequences on drug dose and biological activity of a therapeutic antibody, for example, triggering a severe, or even life threatening immune response in patients. Therefore, antibody therapeutics must be characterized for aggregation as part of the quality assurance process to obtain regulatory approval.
Dynamic Light Scattering (DLS)
DLS, also known as Photon Correlation Spectroscopy (PCS) or Quasi-elastic Light Scattering (QELS), is commonly used to measure aggregates in macromolecular solutions, or to measure the sizes of proteins, nucleic acids, and complexes. It is also a useful tool to determine the particle size distribution of protein therapeutic formulations and other similar bioformulations. In a DLS test, the sample is illuminated by a laser beam and the fluctuations of the scattered light are determined at a known scattering angle θ by a fast photon detector.
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